Volunteers' perceived preparedness, training, experiences and satisfaction in a mass COVID-19 pandemic vaccine clinic

In this paper, we present formal and informal volunteers' perceived experiences of a mass vaccination clinic for COVID-19 in central Texas. Volunteers at one or more of our team's vaccination events responded to an anonymous survey to share perceptions of their preparedness, training experiences, communication effectiveness and satisfaction, to help us identify opportunities to improve volunteer training and engagement for responses to pandemics. Overall, the volunteers perceived their work to be meaningful, felt prepared and were satisfied with their experiences as volunteers. A dedicated team that communicates well and emphasizes a team approach is key to success, especially in unprecedented situations such as the COVID-19 pandemic. Implications for future volunteer training and involvement in disaster responses are discussed.

Change detection of travel behavior: a case study of COVID-19

Travel behavior is important in many fields, such as urban management and disaster management. Since the breakout of COVID-19, many people have changed their preference in travel, which is called travel behavior pattern, to respond to the impact of COVID-19. Understanding when, how, and why people change their travel behavior patterns is significant for antiepidemic and estimating the impact of COVID-19 on human society. However, most current studies ignore that travel behavior is multi-dimensions, and it can be a barrier to understanding travel behavior change. To fill up the vacuum of current research, we used an online Bayesian change detection method to detect individual travel behavior pattern change from big mobile trajectory data. For the low data quality problem caused by various and uneven, we design a novel Monte Carlo data grading framework to assess data quality and filter useable data and thus avoid unreliable results. The analysis result shows Tokyo experienced 6 phases of travel behavior change since 2020, and the change was driven by policies to some extent, especially in the frequency dimension and spatial dimension. Also, the correlation analysis indicates the correlation between four travel behavior dimension dimensions, and the infection number provides us with knowledge about how people will make a change in their travel behavior in the COVID-19 period. © 2023 Elsevier Inc. All rights reserved.

Expert advice on vaccination against COVID-19 for patients with mental disorders.

The COVID-19 epidemic has caused serious and long-lasting health and social harm. Vaccination is considered as the most effective way to prevent the COVID-19 epidemic. Patients with mental disorders are at high risk of COVID-19 infection who are in urgent need to get protection. However, due to the particularity of their conditions, whether these patients should be vaccinated has become a tough issue that obsesses doctors, patients with mental disorders, and their families. In light of this issue, this article provides expert advice on the safety, legal and ethical issues of vaccination for patients with mental disorders to regulate the vaccination of these vulnerable populations against COVID-19.Copyright © 2022 Chinese Journal of Psychiatry. All rights reserved.

A Hybrid Model of Deep Learning Features and Clinical Features for Severe Cases Predication of COVID-19

COVID-19 has spread around the world since 2019. Approximately 6.5% of COVID-19 a risk of developing severe disease with high mortality rate. To reduce the mortality rate and provide appropriate treatment, this research established an integrated models with to predict the clinical outcome of COVID-19 patients with clinical, deep learning and radiomics features. To obtain the optimal feature combination for prediction, 9 clinical features combination was selected from all available clinical factors after using LASSO, 18 deep learning features from U-Net architecture, and 9 radiomics features from segmentation result. A total of 213 COVID-19 patients and 335 non-COVID-19 patients from 5 hospitals were enrolled and used as training and test sample in this research. The proposed model obtained an accuracy, precision, recall, specificity, F1-score and ROC curve of 0.971, 0.943, 0.937, 0.974, 0.941 and 0.979, respectively, which exceeds the related work using only clinical, deep learning or radiomics factors. © 2023 SPIE.

Characteristics of the Health Service Psychologist Workforce

This article describes major employment and demographic trends in the health service psychologist workforce with information provided about clinical psychology where available. Workforce projections suggest the workforce is insufficiently sized and inadequately trained to respond to future health needs, such as those from Hispanic and older adult populations. Still, there are encouraging shifts toward greater racial/ethnic diversity in the workforce and increasing ratings of knowledge about working with diverse populations. Future directions consider implications for education and practice, such as the possible role of telehealth and the impact of the COVID-19 pandemic. © 2022 Elsevier Ltd. All rights reserved

A Data-Driven Context-Aware Health Inference System for Children during School Closures

Many countries have implemented school closures due to the outbreak of the COVID-19 pandemic, which has inevitably affected children's physical and mental health. It is vital for parents to pay special attention to their children's health status during school closures. However, it is difficult for parents to recognize the changes in their children's health, especially without visible symptoms, such as psychosocial functioning in mental health. Moreover, healthcare resources and understanding of the health and societal impact of COVID-19 are quite limited during the pandemic. Against this background, we collected real-world datasets from 1,172 children in Hong Kong during four time periods under different pandemic and school closure conditions from September 2019 to January 2022. Based on these data, we first perform exploratory data analysis to explore the impact of school closures on six health indicators, including physical activity intensity, physical functioning, self-rated health, psychosocial functioning, resilience, and connectedness. We further study the correlation between children's contextual characteristics (i.e., demographics, socioeconomic status, electronic device usage patterns, financial satisfaction, academic performance, sleep pattern, exercise habits, and dietary patterns) and the six health indicators. Subsequently, a health inference system is designed and developed to infer children's health status based on their contextual features to derive the risk factors of the six health indicators. The evaluation and case studies on real-world datasets show that this health inference system can help parents and authorities better understand key factors correlated with children's health status during school closures. © 2023 ACM.

Progress of the development of anti-COVID-19 drugs

Since the outbreak of the novel coronavirus (SARS-CoV-2) disease COVID-19 (also known as 2019-nCoV) caused by SARS-CoV-2 in the end of 2019, it has spread rapidly in worldwide. Besides developing effective vaccines, it is urgent to develop safe and effective anti-SARS-CoV-2 drugs to fight this disease. Paxlovid, molnupiravir, sotrovimab and bebtelovimab are urgently authorized by FDA have been proved to be effective against Omicron. This manuscript mainly reviews the recent progress of effective inhibitors against the virus in the world, including receptor inhibitors, antibodies, natural product inhibitors, synthetic inhibitors and broad-spectrum antiviral drugs that are effective against other RNA viruses. © 2023, Chinese Pharmaceutical Association. All rights reserved.

If you are in, you will understand: A new ‘dress code' on TikTok is reframing lesbian teens' safe space

I intend to offer in this article a visualized research of teenager lesbian style on TikTok and a discourse of queer safe spaces in networked contexts. Due to the influence of the queer feminist movement, the social acceptance of queerness has increased in most countries. Lesbian, gay, bisexual, transgender and questioning groups are no longer limited by the gay ‘dress code', which is historically used to protect queer identity from discrimination and violence. During my personal nomadic experience moving from China to the Netherlands, I noticed that it is hard to pick out someone who ‘looks gay' in the street. The freedom of dressing and self-expression has gradually become universal in western countries. Whereas, without legalized same-sex marriage in mainland China, visibility in style is still a signification of sexuality and a way of communication. Beyond the diversity of style, a new form of lesbian ‘dress code' on TikTok has triggered me to examine safe spaces for teenagers. Due to the COVID-19 pandemic, the fashion industry finds itself in a challenging condition, which is accelerating its digital transfor-mation. An increasing number of fashion labels see potential in TikTok as a new public territory to practise self-exploration for numerous teens. By analysing the visual content and interviewing four TikTok creators, this article addresses the gap between public and insider prejudice around codes of dressing. It proposes not only to rethink the relation between fashion and identity but also to ruminate on queer safe space through researching ways of dressing. © 2023 Intellect Ltd Article. English language.

Experts' consensus on severe acute respiratory syndrome coronavirus-2 vaccination of children.

At present, severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection is still rampant worldwide.As of September 10, 2021, there were about 222 million confirmed cases of corona virus disease 2019(COVID-19)and more than 4.6 million deaths worldwide.With the development of COVID-19 vaccines and the gradual vaccination worldwide, the increasing number of cases in children and unvaccinated young people has drawn attention.According to World Health Organization surveillance data, the proportion of COVID-19 infection cases in children gradually increased, and the proportion of cases in the age groups of under 5 years and 5-14 years increased from 1.0% and 2.5% in January 2020 to 2.0% and 8.7% in July 2021, respectively.At present, billions of adults have been vaccinated with various COVID-19 vaccines worldwide, and their protective effects including reducing infection and transmission, reducing severe disease and hospitalization, and reducing death, as well as high safety have been confirmed.Canada, the United States, Europe and other countries have approved the emergency COVID-19 vaccination in children and adolescents aged 12 to 17 years, and China has also approved the phased vaccination of COVID-19 vaccination in children and adolescents aged 3 to 17 years. For smooth advancement and implementation of COVID-19 vaccination in children, academic institutions, including National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, and The Society of Pediatrics, Chinese Medical Association organized relevant experts to reach this consensus on COVID-19 vaccination in children.Copyright © 2021 by the Chinese Medical Association.

Twenty key issues on severe acute respiratory syndrome coronavirus-2 vaccination in children.

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection is still worldwide.As a vulnerable group, severe and dead pediatric cases are also reported.Under this severe epidemic situation, children should be well protected.With the widespread vaccination of SARS-CoV-2 vaccine in adults, the infection rate have decreased.Therefore, SARS-CoV-2 vaccine inoculation for children groups step by step is of great significance to the protection of children and the prevention and control of corona virus disease 2019(COVID-19) as a whole.But the safety of children vaccinated with SARS-CoV-2 vaccine is a main concern of parents.Therefore, in order to ensure the safety of vaccination and the implementation of vaccination work, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health and the Society of Pediatrics, Chinese Medical Association organized experts to interpret the main issue of parents about SARS-CoV-2 vaccine for children, in order to answer the doubts of parents.Copyright © 2021 by the Chinese Medical Association.

Retrospective Analysis of the Duration of Hospitalization of Imported Patients Infected with SARS-CoV-2 in Guangzhou, 2021

The pandemic of coronavirus disease 2019 is "not over,"in fact, the "dynamic clearing"policy for SARS-CoV-2 control and prevention in China has been firmly enforced. This study aimed to analyze the clinical symptoms and dynamic viral RNA changes in 2021 at Guangzhou Eighth People's Hospital. This study showed that 31.4% of the patients (695/2212) tested negative for viral RNA from admission to the final release from quarantine. Of all negative cases, 86.5% (601/695) remained in the hospital for no more than 5 days and were asymptomatic or mild. Among the remaining 402 patients who stayed for no more than 5 days, 76.4% (307/402) were viral RNA retest positive during the isolation stage. However, 96.4% of the peak viral RNA (296/307) was over Ct = 33 cycles during the isolation stage. © Wolters Kluwer Health, Inc. All rights reserved.

Diagnosis, treatment and prevention of 2019 novel coronavirus infection in children: experts' consensus statement (Third Edition).

2019 novel coronavirus(2019-nCoV) outbreak is one of the public health emergency of international concern.Since the 2019-nCoV outbreak, China has been adopting strict prevention and control measures, and has achieved remarkable results in the initial stage of prevention and control.However, some imported cases and sporadic regional cases have been found, and even short-term regional epidemics have occurred, indicating that the preventing and control against the epidemic remains grim.With the change of the incidence proportion and the number of cases in children under 18 years old, some new special symptoms and complications have appeared in children patients.In addition, with the occurrence of virus mutation, it has not only attracted attention from all parties, but also proposed a new topic for the prevention and treatment of 2019-nCoV infection in children of China.Based on the second edition, the present consensus further summarizes the clinical characteristics and experience of children's cases, and puts forward recommendations on the diagnostic criteria, laboratory examination, treatment, prevention and control of children's cases for providing reference for further guidance of treatment of 2019-nCoV infection in children.Copyright © 2021 Chinese Medical Association

Dual effects of supplemental oxygen on pulmonary infection, inflammatory lung injury, and neuromodulation in aging and COVID-19.

Clinical studies have shown a significant positive correlation between age and the likelihood of being infected with SARS-CoV-2. This increased susceptibility is positively correlated with chronic inflammation and compromised neurocognitive functions. Postmortem analyses suggest that acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), with systemic and lung hyperinflammation, can cause significant morbidity and mortality in COVID-19 patients. Supraphysiological supplemental oxygen, also known as hyperoxia, is commonly used to treat decreased blood oxygen saturation in COVID-19 patients. However, prolonged exposure to hyperoxia alone can cause oxygen toxicity, due to an excessive increase in the levels of reactive oxygen species (ROS), which can overwhelm the cellular antioxidant capacity. Subsequently, this causes oxidative cellular damage and increased levels of aging biomarkers, such as telomere shortening and inflammaging. The oxidative stress in the lungs and brain can compromise innate immunity, resulting in an increased susceptibility to secondary lung infections, impaired neurocognitive functions, and dysregulated hyperinflammation, which can lead to ALI/ARDS, and even death. Studies indicate that lung inflammation is regulated by the central nervous system, notably, the cholinergic anti-inflammatory pathway (CAIP), which is innervated by the vagus nerve and α7 nicotinic acetylcholine receptors (α7nAChRs) on lung cells, particularly lung macrophages. The activation of α7nAChRs attenuates oxygen toxicity in the lungs and improves clinical outcomes by restoring hyperoxia-compromised innate immunity. Mechanistically, α7nAChR agonist (e.g., GAT 107 and GTS-21) can regulate redox signaling by 1) activating Nrf2, a master regulator of the antioxidant response and a cytoprotective defense system, which can decrease cellular damage caused by ROS and 2) inhibiting the activation of the NF-κB-mediated inflammatory response. Notably, GTS-21 has been shown to be safe and it improves neurocognitive functions in humans. Therefore, targeting the α7nAChR may represent a viable therapeutic approach for attenuating dysregulated hyperinflammation-mediated ARDS and sepsis in COVID-19 patients receiving prolonged oxygen therapy.

Progress of the development of anti-COVID-19 drugs

Since the outbreak of the novel coronavirus (SARS-CoV-2) disease COVID-19 (also known as 2019-nCoV) caused by SARS-CoV-2 in the end of 2019, it has spread rapidly in worldwide. Besides developing effective vaccines, it is urgent to develop safe and effective anti-SARS-CoV-2 drugs to fight this disease. Paxlovid, molnupiravir, sotrovimab and bebtelovimab are urgently authorized by FDA have been proved to be effective against Omicron. This manuscript mainly reviews the recent progress of effective inhibitors against the virus in the world, including receptor inhibitors, antibodies, natural product inhibitors, synthetic inhibitors and broad-spectrum antiviral drugs that are effective against other RNA viruses.

Progress of the development of anti-COVID-19 drugs

Since the outbreak of the novel coronavirus (SARS-CoV-2) disease COVID-19 (also known as 2019-nCoV) caused by SARS-CoV-2 in the end of 2019, it has spread rapidly in worldwide. Besides developing effective vaccines, it is urgent to develop safe and effective anti-SARS-CoV-2 drugs to fight this disease. Paxlovid, molnupiravir, sotrovimab and bebtelovimab are urgently authorized by FDA have been proved to be effective against Omicron. This manuscript mainly reviews the recent progress of effective inhibitors against the virus in the world, including receptor inhibitors, antibodies, natural product inhibitors, synthetic inhibitors and broad-spectrum antiviral drugs that are effective against other RNA viruses. © 2023, Chinese Pharmaceutical Association. All rights reserved.

A systems view of responding to the COVID-19 pandemic: A causal loop model for Taiwan's approach

Since the worldwide outbreak of the COVID-19 pandemic in December 2019, Taiwan has successfully stopped the spread of COVID-19. The policies and works of the epidemic control are a complex and dynamic process. This study applied the methodology of system dynamics to explore the structure of the COVID-19 epidemic control system in Taiwan and analysed its system behaviours. The results show that the system is composed of key subsystems, such as national health insurance and quarantine, combined with government policies. Joint efforts among the central and local governments and the general public have been made to strengthen the quarantine of border entrants, encourage the public to wear masks and employ technology for contact tracing and tracking down those being tested positive with COVID-19. Together with the efficient increase in the capacity of testing and medical treatments, these measures can effectively reach a balance between epidemic control and economic activities. © 2022 John Wiley & Sons, Ltd.

Progress of the development of anti-COVID-19 drugs

Since the outbreak of the novel coronavirus (SARS-CoV-2) disease COVID-19 (also known as 2019-nCoV) caused by SARS-CoV-2 in the end of 2019, it has spread rapidly in worldwide. Besides developing effective vaccines, it is urgent to develop safe and effective anti-SARS-CoV-2 drugs to fight this disease. Paxlovid, molnupiravir, sotrovimab and bebtelovimab are urgently authorized by FDA have been proved to be effective against Omicron. This manuscript mainly reviews the recent progress of effective inhibitors against the virus in the world, including receptor inhibitors, antibodies, natural product inhibitors, synthetic inhibitors and broad-spectrum antiviral drugs that are effective against other RNA viruses. © 2023, Chinese Pharmaceutical Association. All rights reserved.